Neuraxial (epidural and intrathecal) opioids for intractable pain
نویسندگان
چکیده
منابع مشابه
Intrathecal opioids for chronic pain: a call for evidence.
The first implanted fixed rate pumps were used in humans in the mid-1980s [1]. In 1991, Medtronic® released the first programmable pump for human use [2]. The majority of the research and reports concern programmable pumps, and the best and most current systematic review of the literature only identified manuscripts on these devices, and only considered chronic nonmalignant pain (AKA chronic no...
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In 1968, Melzack and Wall put forward their ‘gate control theory’ proposing that the spinal cord was a potential target site for modulation of pain signals. This changed our concepts about nociceptive transmission and laid the foundation for further research into dorsal horn opioid pharmacology. This led to the discovery of opioid receptors by Pert and Snyder in 1973 and the subsequent identifi...
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Hitchcock's original method of hypothermic subarachnoid irrigation employed both temperature and osmolarity. Spinal cooling was then abandoned in favour of intrathecal injection of normothermic hypertonic salilne. Modifications of the procedure that followed have continued to accept hyperosmolarity as the factor causing pain relief. Fifty patients were treated by a technique evolved to enhance ...
متن کاملIntrathecal and epidural narcotics.
This paper presents an overall review of epidural and intrathecal narcotics. The early laboratory studies and initial clinical applications are presented. This is followed by a description of the mechanism of action of narcotics acting both intrathecally and epidurally, and some of the similarities and differences between narcotics and local anesthetic drugs. Technique, dosages, indications, an...
متن کاملIntrathecal morphine reduces breakthrough pain during labour epidural analgesia.
BACKGROUND When using the combined spinal-epidural (CSE) technique for labour analgesia, parturients often experience breakthrough pain after the spinal medication has receded. We tested the hypothesis that a small dose of intrathecal morphine would reduce breakthrough pain. METHODS This was a randomized, double-blind, placebo-controlled trial. Subjects were randomized to receive either 100 m...
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ژورنال
عنوان ژورنال: British Journal of Pain
سال: 2012
ISSN: 2049-4637,2049-4645
DOI: 10.1177/2049463712439256